British Air Force Typhoon FGR4s have conducted a mission with France's air force in a combined operation on an hidden munitions depot in Syrian territory operated by the IS group, per a report from the British defence ministry.
The location, identified by reconnaissance, was assessed as containing munitions and bombs, the statement said, and was located in mountains just north of the ancient city of Palmyra in Syria's central region.
"Our fighter planes used Paveway IV guided bombs to hit a number of entry passages leading to the site... initial indications indicate the strike was effective," the MoD said.
There was no evidence of any civilian impact in the operation conducted Saturday night and each participating jet returned to base without incident, the MoD added.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as Daesh - imposed extremist governance over significant areas in Iraq and Syria prior to its 2019 collapse.
"This strike shows our UK leadership, and commitment to work closely with our partners, to eliminate any revival of IS and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief John Healey remarked.
British military aircraft have performed overwatch operations over Syria to "prevent any attempted comeback" of IS after its defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I want to thank the personnel of the UK armed forces involved in this strike for their expertise and their courage," the Defence Secretary added. "They were part of a great many British troops deployed over Christmas and New Year. This mission, to remove terrorist threats who pose a risk to our security, highlights how our armed forces are ready to step up, continuously, protecting the UK at home and powerful internationally."
In December, the US military conducted what it termed a "major assault" targeting Daesh sites in Syria, subsequent to an assault killed two US servicemembers and a civilian interpreter in Palmyra.
The United Nations estimates Daesh still boasts roughly 5-7 thousand fighters in Iraq and Syria.